Indications of Lantid 30 mg

Lantid 30 mg is indicated for: Short term treatment of active duodenal ulcer Maintenance of healed duodenal ulcers Short term treatment of active benign gastric ulcers Short term treatment of active erosive esophagitis Maintenance of healing of erosive esophagitis ... Read moreLantid 30 mg is indicated for: Short term treatment of active duodenal ulcer Maintenance of healed duodenal ulcers Short term treatment of active benign gastric ulcers Short term treatment of active erosive esophagitis Maintenance of healing of erosive esophagitis Pathological hypersecretory conditions including Zollinger- Ellison Syndrome H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Theropeutic Class

Proton Pump Inhibitor

Pharmacology

Lantid 30 mg is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H /K ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Dosage and Administration of Lantid 30 mg

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.

Dosage of Lantid 30 mg

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.

Interaction of Lantid 30 mg

Lantid 30 mg appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Lantid 30 mg on the oral combined contraceptive pill. Further assessment is currently underway. Physiological changes similar to those found with Omeprazole are likely to take place because of the reduction in gastric acid, which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.

Contraindications

Lantid 30 mg is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects of Lantid 30 mg

Severe or irreversible adverse effects: The possible induction of carcinoid tumors by profound acid suppression, and a rise in serum gastrin may occur. There is a rise in serum gastrin levels in the first 3 months of treatment, which are then maintained though at a lower level than those found in pernicious anaemia. Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori infection may accelerate the development of atrophic gastritis.Symptomatic adverse effect: Dose dependent diarrhoea occurs with an incidence of about 4percent at 30 mg per day, rising to 8percent at 60 mg per day. Headache occurs in 2-3percent of treated patients

Pregnancy and Lactation

Lantid 30 mg should be avoided in pregnancy unless there are compelling reasons.

Precautions and Warnings

Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.

Storage Conditions

Store at 25° C.

Use In Special Populations

Neonates:There is no relevant human data. The drug is not recommended for use with neonates.Children: The youngest person to have received Lantid 30 mg in clinical trials was 13 years old.The Elderly: No problems have been encoun- tered in clinical use and there has been no increase in adverse drug reaction in the elderly.

Drug Classes

Proton Pump Inhibitor

Mode Of Action

Lantid 30 mg is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H /K ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Pregnancy

Lantid 30 mg should be avoided in pregnancy unless there are compelling reasons.

Pediatric Uses

Neonates:There is no relevant human data. The drug is not recommended for use with neonates.Children: The youngest person to have received Lantid 30 mg in clinical trials was 13 years old.The Elderly: No problems have been encoun- tered in clinical use and there has been no increase in adverse drug reaction in the elderly.