Indications of Carnovas HZ 5 mg 12.5 mg

Essential hypertension

Theropeutic Class

Combined antihypertensive preparations

Pharmacology

The Combination of these ingredients has an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone. This combination has mild vasodilating properties which reduces heart rate and blood pressure in hypertensive patients. Hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption which directly increase the excretion of sodium and chloride in approximately equivalent amounts. The diuretic action of Hydrochlorothiazide reduces plasma volume, increases plasma renin activity and increases aldosterone secretion.

Dosage and Administration of Carnovas HZ 5 mg 12.5 mg

Once daily, preferably at the same time every day.

Dosage of Carnovas HZ 5 mg 12.5 mg

Once daily, preferably at the same time every day.

Interaction of Carnovas HZ 5 mg 12.5 mg

Nebivolol: Class I and III Antiarrhythmics, Calcium channel blocker (Verapamil/Diltiazem) Centrally-acting antihypertensives, Anaesthetics Antipsychotics, Antidepressants, NSAIDs Hydrochlorothiazide: Drugs affecting Potassium and Calcium level Non-steroidal anti-inflammatory drugs (NSAIDs) Concomitant administration of this combination with Antipsychotics, Tricyclic Antidepressants and Barbiturates may enhance the hypotensive effect and lead to postural hypotension.

Contraindications

Hypersensitivity to the active substances, Liver function impairment. Severe renal insufficiency (Creatinine clearance andlt; 30 ml/min.), Bradycardia, Hypotension

Side Effects of Carnovas HZ 5 mg 12.5 mg

Nebivolol: Headache, Dizziness, Tiredness, Diarrhoea, Constipation, Nausea etc.Hydrochlorothiazide: Vertigo, Itchiness, Rash, Increased sensitivity of skin to sunlight etc.

Pregnancy and Lactation

This combination is not recommended during pregnancy. It is also not recommended for mothers who are breast-feeding

Precautions and Warnings

Nebivolol: Beta-blockers should not be used in patients with untreated Congestive Heart Failure (CHF) and bradycardia. In patients with Chronic Obstructive Pulmonary Diseases (COPD), beta-blockers should be used with caution as airway constriction may be aggravated.Hydrochlorothiazide: In patients with renal disease, thiazides may increase azotaemia. If progressive renal impairment becomes evident, careful reappraisal of therapy is necessary. Thiazides can cause fluid or electrolyte imbalance. Thiazides may decrease urinary calcium excretion and may cause slight elevation of serum calcium in the absence of known disorders of calcium metabolism

Overdose Effects of Carnovas HZ 5 mg 12.5 mg

No data are available on Overdosage. Overdosage with Hydrochlorothiazide is associated with electrolyte depletion and dehydration resulting from excessive diuresis.

Storage Conditions

Protect from light and moisture. Store below 30° C. Keep out of reach of children.

Use In Special Populations

Use in children is not recommended.

Drug Classes

Combined antihypertensive preparations

Mode Of Action

The Combination of these ingredients has an additive antihypertensive effect, reducing blood pressure to a greater degree than either component alone. This combination has mild vasodilating properties which reduces heart rate and blood pressure in hypertensive patients. Hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption which directly increase the excretion of sodium and chloride in approximately equivalent amounts. The diuretic action of Hydrochlorothiazide reduces plasma volume, increases plasma renin activity and increases aldosterone secretion.

Pregnancy

This combination is not recommended during pregnancy. It is also not recommended for mothers who are breast-feeding

Pediatric Uses

Use in children is not recommended.