Medicine overview
Indications of Seacal-D
This is indicated for the treatment and prevention of osteoporosis, osteomalacia, tetany, hypoparathyroidism, disorders of osteogenesis. Also used as supplement in case of inadequate intake of Calcium in childhood diet, rickets, pregnancy and lactation, elderly patients. Other indications include pancreatitis, phosphate binder in chronic renal failure etc.

Composition
Each film coated tablet contains- Calcium Carbonate 1500 mg (from Coral source) equivalent to elemental Calcium 600 mg Vitamin D3 400 IU as Cholecalciferol Or Calcium Carbonate 1250 mg (from Coral source) equivalent to elemental Calcium 500 mg Vitamin D3 200 IU as Cholecalciferol

Theropeutic Class
Specific mineral and vitamin combined preparations

Pharmacology
Adequate Calcium in the blood is so vital to a wide variety of bodily functions that our internal biochemistry will not tolerate a deficiency even for short periods. Clinical evidence suggests that Calcium is useful for the prevention and treatment of Osteoporosis and associated fractures. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this it stimulates bone formation. Clinical studies also show that Calcium and vitamin D has synergistic effects on bone growth as well as in Osteoporosis and fracture prevention.

Dosage and Administration of Seacal-D
One tablet in the morning and one tablet at night or as directed by the Physician

Dosage of Seacal-D
One tablet once or twice daily with plenty of water or as directed by the physician. Taking in full stomach ensures better absorption.

Interaction of Seacal-D
Oral Calcium can reduce the absorption of tetracycline and fluoride preparations and minimum 3 hours time should be allowed between ingestion of these medications. Thiazide diuretics reduces the renal excretion of Calcium. Phenytoin, barbiturates, glucocorticoids may induce metabolism of Vitamin D3. Concomitant ingestion of certain foods like spinach, cereals, milk and its derivatives may reduce the intestinal uptake of Calcium.

Contraindications
Hypersensitivity to any of the components, hypocalcaemia resulting from overdose of Vitamin D3, hyperparathyroidism, bone metastases, severe renal insufficiency, severe hypercalciuria, renal calculi etc.

Side Effects of Seacal-D
Flatulence, diarrhoea, constipation, upper GI discomfort etc. are rare manifestation. Hypercalcaemia due to prolong use has rarely been reported.

Pregnancy and Lactation
It should be used as directed by the physician during Pregnancy and Lactation.

Precautions and Warnings
In presence of mild hypercalciuria, careful monitoring with reduction of dose may be needed. Plasma and serum Calcium level should be monitored in mild to moderate renal impairment and also in case of long-term use. Patients with renal stones or with such previous history should also take precautions.

Overdose Effects of Seacal-D
At high doses it may result in nausea, vomiting, dizziness, anorexia, abdominal cramps, headache, constipation, irritability etc. Treatment includes cessation of therapy and adequate rehydration.

Storage Conditions
Store at temperature of below 30°C, protect from light and moisture. Keep out of reach of children.

Drug Classes
Specific mineral and vitamin combined preparations

Mode Of Action
This is a Calcium and Vitamin D3 preparation where Calcium Carbonate is sourced from coral origin. The Calcium Carbonate from Coral has a chemical structure that is very similar to the composition of human bone. Coral Calcium is similar to other sources but ensures better absorption. Vitamin D3 aids in the absorption of Calcium from GI tract and helps to maintain Calcium balance in the body.

Pregnancy
This can be given to pregnant and lactating mothers as per recommendation of physician.