Indications of Neurobest

Neurobest is indicated for the treatment of vitamin B1, B6 and B12 deficiency syndrome. It is also indicated for the supportive treatment of neuritis and non-inflammatory diseases of the nerves, e.g.- Diabetic neuropathy, Peripheral neuralgin, Lumbago, Myalgia, Optic neuritis, Sciatica, Facial neuralgia, Intercostal neuralgia, Spinal pain.

Composition

Each film-coated tablet contains- Vitamin B1 (Thiamine Mononitrate) 100 mg Vitamin B6 (Pyridoxine Hydrochloride) 200 mg Vitamin B12 (Cyanocobalamin) 200 microgram. Each 3 ml ampoule contains- Thiamine Hydrochloride (Vitamin B1) 100 mg Pyridoxine Hydrochloride (Vitamin B6) 100 mg Cyanocobalamin (Vitamin B12) 1000 mcg.

Theropeutic Class

Specific combined vitamin preparations

Pharmacology

Neurobest is a combined preparation of Vitamin B1 (Thiamine Mononitrate), Vitamin B6 (Pyridoxine Hydrochloride) and Vitamin B12 (Cyanocobalamin). These vitamins play an essential role as co-enzyme in the metabolism of nervous system. supports the regeneration of nerve fibers and myelin sheath by activation of the nerve cell metabolism and the natural repair mechanism.

Dosage and Administration of Neurobest

Tablets: 1 to 3 tablets per day or as directed by the physician. Injection: Ampules are preferably injected intramuscularly (deep intragluteal). In severe cases 1 ampoule daily until the acute symptoms subside. For milder cases and follow up therapy 2 to 3 ampoules per week.

Dosage of Neurobest

Tablet: 1-3 Tablets per day or as advised by the physician. Injection: In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician. In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly. Use in children: There is no information on the use of this drug in children.

Interaction of Neurobest

No drug interaction has been reported yet.

Contraindications

Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.

Side Effects of Neurobest

Generally well tolerated but allergic reactions may be observed in few cases.

Pregnancy and Lactation

No risks have become known associated with the use of this combination during pregnancy at the recommended dosage. Vitamin B1, B6 and B12 are secreted into the breast milk but risks of overdose for the infant are not known.

Precautions and Warnings

Cyanocobalamin should not be given in patients with subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.

Overdose Effects of Neurobest

No overdosage symptoms are to be expected in the recommended dosage. If there is known overdose then treatment is symptomatic and supportive.

Storage Conditions

Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

Drug Classes

Specific combined vitamin preparations

Mode Of Action

Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression and eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness, tingling and lowers the risk of heart diseases.The vitamin ingredients are absorbed well in per oral reception. It is widely distributed to most tissues and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.

Pregnancy

Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy and lactation.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.