Indications of Seclo 20 mg

Seclo 20 mg is indicated for the treatment of- Duodenal and gastric ulcer. Gastric and duodenal ulcers brought on by NSAIDs. In individuals who have a history of duodenal and stomach ulcers brought on by NSAIDs, as a preventative treatment. The disease of gastroesophageal reflux. care of acid reflux illness throughout the long term. dyspepsia brought on by acid. severe reflux esophagitis with ulcers. prevention of aspiration of acid while under general anesthesia. syndrome of Zollinger-Ellison. Peptic ulcer brought on by Helicobacter pylori.

Theropeutic Class

Proton Pump Blocker

Pharmacology

An inhibitor of stomach acid secretion is Seclo 20 mg, a benzimidazole replacement. By inhibiting the hydrogen-potassium-adenosine triphosphatase (H plus/K plus ATPase) enzyme system in the gastric parietal cell, it prevents the release of gastric acid.

Following oral administration, the antisecretory effect starts to take effect in about an hour, peaks in two hours, and the inhibition of secretion lasts up to 72 hours. Secretory activity gradually resumes when the medicine is stopped, over a period of 3 to 5 days.

Dosage of Seclo 20 mg

Oral- Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration; in severe or recurrent cases, dose to be increased to 40 mg daily;

maintenance dose for recurrent duodenal ulcer, 20 mg once daily; in prevention of relapse in duodenal ulcer, 10-20 mg daily. NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks, if not fully healed.

20 mg once daily is used as prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers. Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks,

continued for further 4-8 weeks, if not fully healed; 40 mg once daily has been given for 8 weeks in gastro-esophageal reflux disease, refractory to other treatment; maintenance dose is 20 mg once daily.

Long-term management of acid reflux disease: 10-20 mg daily. Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks.

Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery. Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily (If daily dose is more than 80 mg, 2 divided dose should be used).

Helicobacter pylori eradication regimen in peptic ulcer disease: Seclo 20 mg is recommended at a dose of 20 mg twice daily in association with antimicrobial agents as detailed below: Amoxicillin 500 mg and Metronidazole 400 mg both three times a day for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice a day for one week, or Amoxicillin 1 g and Clarithromycin 500 mg both twice a day for one week.

Paeditaric use in severe ulcerating reflux esophagitis (Child