Indications of Ace Plus 500 mg 65 mg
In the situation described below, Ace Plus 500 mg 65 mg is indicated: Headache Migraine Toothache Neuralgia Feverishness Period pain Sore throat Backache Help to reduce the temperature Aches and pain of colds and flu

Theropeutic Class
Non opioid analgesics

Pharmacology
Ace Plus 500 mg 65 mg is the result of mixing caffeine with paracetamol (acetaminophen). It has antipyretic and analgesic qualities. The analgesic action of paracetamol is enhanced by caffeine. One of the most popular and safest analgesics and antipyretics is paracetamol. It acts as an analgesic by lowering the pain threshold and as an antipyretic by affecting the hypothalamus heat regulatory area. An alkaloid similar to theophylline and Xanthine, caffeine is a stimulant. Caffeine improves the solubility and transmembrane permeability of paracetamol through intermolecular interaction with it. Caffeine also raises one's pain tolerance and pain threshold. Another advantage of caffeine for the treatment of migraine and headaches is its inherent ability to increase cerebral blood vessel tone.

Dosage and Administration of Ace Plus 500 mg 65 mg
Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily. Child dose: Not recommended for children below 12 years.

Dosage of Ace Plus 500 mg 65 mg
Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily. Child dose: Not recommended for children below 12 years.

Interaction of Ace Plus 500 mg 65 mg
Anticonvulsants may lower serum levels (e.g. phenytoin, barbiturates, carbamazepine). Warfarin and other coumarins' anticoagulant effects may be strengthened by extended use. increased absorption of domperidone with metoclopramide. Probenecid may lead to an increase in serum levels. Chloramphenicol serum concentrations might rise. Colestyramine within 1 hour of administration may decrease absorption. Phenothiazine may significantly increase hypothermia.

Contraindications
Those with severe renal function impairment and hepatic illness should not use paracetamol (Viral Hepatitis). known sensitivity to caffeine or aspirin.

Side Effects of Ace Plus 500 mg 65 mg
Although hematological responses such as thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been described, paracetamol side effects are typically moderate. There are sporadic cases of pancreatitis, skin rashes, and other adverse responses.

Pregnancy and Lactation
Doctors should be consulted before pregnant women take caffeine and paracetamol. It is safe to take caffeine and paracetamol during breastfeeding.

Precautions and Warnings
The following situations necessitate cautious administration of caffeine and paracetamol: While taking additional hepatotoxic medications by patients with hepatic or renal impairment. Avoid using the medicine for an extended period of time without first consulting a doctor.

Overdose Effects of Ace Plus 500 mg 65 mg
Pallor, nausea, vomiting, anorexia, and stomach discomfort are the initial 24-hour paracetamol overdose symptoms. 12 to 40 hours after intake, liver damage might be noticed. There may be metabolic acidosis and abnormalities in glucose metabolism.

Storage Conditions
Keep away from light and moisture in a cool, dry location. Keep all medications out of the children's reach.

Drug Classes
Non opioid analgesics

Mode Of Action
Ace Plus 500 mg 65 mg contains both caffeine and paracetamol. The antipyretic and analgesic effects of paracetamol are combined with a negligible anti-inflammatory effect. A xanthine derivative that resembles theophylline, caffeine is an alkaloid. Caffeine improves the solubility and transmembrane permeability of paracetamol through intermolecular interaction with it. Coffee also raises one's pain tolerance and pain threshold. Another advantage of caffeine for treating migraines and headaches is its inherent ability to increase brain vascular tone.

Pregnancy
Doctors should be consulted before pregnant women take caffeine and paracetamol. It is safe to take caffeine and paracetamol during breastfeeding.